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Uniting Unique People in a Unique World

International Mosaic Down Syndrome Association

PO Box 321, Stow, MA 01775

1-855-IMDSA-21

DEVELOPMENTAL MILESTONES

COMPARISONS OF MOSAIC & NON-MOSAIC DOWN SYNDROME

In the 1996 mosaic Down syndrome research publication of the Medical College of Virginia (MCV), Virginia Commonwealth University, researchers matched 28 pairs of individuals with mosaic and non-mosaic Down syndrome. This match was to compare the similarities and differences of mosaic and non-mosaic Down syndrome. With the exception of speech, there was a trend toward individuals with mosaic DS reaching the milestone evaluated at an earlier age than those with non-mosaic Down syndrome. However, a clear difference (identified by statistical testing) was apparent only for crawling and walking.

MilestoneMosaic Down syndromeNon-Mosaic DS
Rolled Over
4.65 months
5.06 months
Sat Alone
8.59 months
9.44 months
*Crawled
11.24 months
13.89 months
*Walked Alone
20.54 months
24.33 months

Spoke first word other than mama/dada

19.13 months
17.94 months
Drank from cup alone
17.00 months
19.64 months
Walked up stairs
24.77 months
34.20 months

* = statistical difference between mosaic and non-mosaic groups

IMDSA recognizes that this is an average age and in no way an absolute guideline for when individuals with mosaic Down syndrome will meet their milestones .

COMPARISONS OF CHILDREN W/MOSAIC DOWN SYNDROME AND SIBLINGS

In another part of this study 45 individuals ranging in the age of 4 months to 33 yrs were compared to their siblings when asked when each group met developmental milestones.

In Months
Children w/MDS
Siblings
Milestone
^Avg
Range
^Avg
Range
Rolled Over
4.5
1-12
3.5
1-6
*Sat Alone
8.5
4-15
6
4-8.5
*Crawled
11
6-23
7
3-11

**Spoke first word

18
6-60
11
5-18

*Walked

20
9-30
11
8-16
*Walked up stairs
25
9-48
17
10-24
*Toilet Trained
44
20-72+
27
17-48
*Self Dressed
49
32-96
36
24-60

* = statistical difference between children with mosaicism and their siblings

** = first word other than mama or dada

* Age in chart is counted by months

^ - AVG = Average

IMDSA recognizes that there is a wide age range in developmental milestones for children with mosaic Down syndrome and in most cases, a significant developmental delay when compared to their siblings according to this research conducted by MCV.

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